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Diabetes Care (2017) 40:107381

10.1093/molehr/6.5.397

Its Invisible Without the invasion of surgical tools, the skins surface remains unblemished

Comorbidities included hypertensive diseases (I10-I16), Type 2 diabetes mellitus (E11), chronic lower respiratory diseases (J40-J47), neoplasms (C00-D49), psychoactive substance use (F10-F19), ischemic heart diseases (I20-I25), chronic kidney disease (N18), and cerebrovascular diseases (I60-I69)

Based on this research, it appears a significant proportion of metformins action could be attributed to its effect on the lower digestive tract (Buse 2016)